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Sindiso Nyathi1, Izabela M Rezende2, Katharine S Walter3

  • 1Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, 94305, USA. sindiso.nyathi@yale.edu.

Nature communications
|September 7, 2024
PubMed
概括

肯尼亚的登革热病毒-2 (DENV-2) 显示了两个主要的遗传系,与肯尼亚和布基纳法索的疫情有关. 这些DENV-2菌株是从东亚和东南亚进口的,推动了非洲的区域传播.

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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