相关实验视频
Updated: Jun 13, 2026

04:34
Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis
Published on: June 15, 2011
18.3K
狼抗凝剂的 (逆) 悖论:一个病例报告
Hiren Kalyani1, Mayank Goyal1, Tejaswee Banavathu1
1Department of Rheumatology, Max Super Speciality Hospital, New Delhi, India.
Lupus
|September 8, 2024
概括
这项案例研究突出显示,在患有系统性红斑狼 (SLE) 的儿童中,狼抗凝剂低血血症综合征 (LAHS) 发生. 早期诊断和治疗导致显著的临床改善和正常化的凝血参数.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 可能与抗脂综合征 (APS) 相关.
- 抗脂综合征涉及反复发生的血栓事件或由于抗脂抗体引起的产科并发症.
- 狼抗凝剂低血血症综合征 (LAHS) 是一种罕见的病症,伴有出血和凝血病.
研究的目的:
- 在诊断为SLE的儿科患者中报告LAHS的罕见病例.
- 描述临床表现,诊断工作和儿童LAHS的管理.
- 强调在患有SLE和出血症的儿童中识别LAHS的重要性.
主要方法:
- 一个7岁的女孩出现了发烧,表面血栓炎和粘膜出血.
- 诊断工作包括凝血图,自身免疫标记物 (ANA,ENA),抗脂抗体和特定因子测定.
- 进行了混合研究,以区分抑制剂类型并确定前列血缺乏症.
主要成果:
- 该患者被诊断患有SLE和LAHS,其特点是低血栓激素水平和狼抗凝剂.
- 静脉注射甲基普雷迪尼索隆的治疗导致发烧,出血的缓解,以及INR和补充水平的正常化.
- 长期的治疗包括氧化,mycophenolate mofetil和低剂量阿司匹林用于血栓预防.
结论:
- 在儿童SLE患者中,LAHS是一种可治疗的疾病.
- 及时诊断和免疫抑制疗法对于有利的结果至关重要.
- 这一案例强调了SLE,凝血病和儿童血栓形成风险之间的复杂相互作用.
相关概念视频
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Disorders of Hemostasis
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

