视觉皮层神经元中的每日光感应的转录驱动着下降的发射速率平衡,并稳定了感官处理
Dahlia Kushinsky1, Emmanouil Tsivourakis1, Daniella Apelblat1
1Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel.
Cell reports
|September 8, 2024
概括
每天暴露于光线会触发视觉皮层中的基因表达,稳定神经回路. 转录因子NPAS4维持这种平衡,确保传感处理和感知的一致性.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 感官处理 感官处理
背景情况:
- 神经回路需要在可塑性和稳定性之间保持平衡,以便学习和感知.
- 神经电路中活动诱导的分子稳定性的机制尚不清楚.
研究的目的:
- 研究成年老鼠视觉皮层中功能稳定性背后的分子机制.
- 确定日常感官体验如何影响神经电路稳定性.
主要方法:
- 文字转录学 (Transcriptomics) 是一个学科.
- 电子生理学 电子生理学
- 在成年小鼠体内成像.
主要成果:
- 每天暴露于光线会诱导激发性神经元中的显著基因程序.
- 光会触发刺激/抑制 (E/I) 比率和神经活动的暂时增加.
- 转录因子NPAS4由光诱导,并使E/I比率和神经活动率正常化.
- NPAS4可以稳定神经元的反应特性.
结论:
- 每天的感官输入驱动转录,使E/I比率正常化.
- 这一过程建立了向下射速平衡,这对于感官处理和感知至关重要.
相关概念视频
Photoreceptors and Visual Pathways
5.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.9K
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Channel Rhodopsins
2.5K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
2.5K
The Retina
68.0K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
68.0K


