间歇性臭氧吸入室内灰尘引发的敏感化因子为不良喘表型的原始
Salik Hussain1, Nairrita Majumder2, Md Habibul Hasan Mazumder2
1Department of Physiology, Pharmacology and Toxicology, School of Medicine, West Virginia University, Morgantown, WV, USA; Center for Inhalation Toxicology (iTOX), School of Medicine, West Virginia University, Morgantown, WV, USA; Microbiology, Immunology and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV, USA.
在室内灰尘虫 (HDM) 敏感化期间暴露于臭氧 (O3) 会通过增加气道炎症,过度反应和T H17反应使喘恶化. 这项研究强调了臭氧.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 众所周知,空气污染,特别是臭氧 (O3),会使喘恶化.
- 臭氧在调节过敏敏感性的作用仍然不太清楚.
研究的目的:
- 调查同时暴露于臭氧和家庭灰尘虫敏感性对喘发展的影响.
- 为了确定在敏感化过程中对臭氧的暴露是否会导致更严重的喘表型.
主要方法:
- 小鼠对室内灰尘虫 (HDM) 敏感,并暴露在臭氧 (O3) 或对照条件下.
- 评估肺洗,组织学,肺功能,免疫细胞概况,炎症和免疫球蛋白水平.
- 分析了肺组织和血清中的基因表达,调解剂水平和氧化还原平衡.
主要成果:
- 与单独使用HDM相比,HDM + O3的同时暴露显著增加了气道炎症和过度反应.
- 在同时暴露组中观察到血清总IgG,IgE和HDM特异性IgG1的升高.
- 增加了激活的树突细胞,T淋巴细胞和IL-17通路激活,以及还原氧失衡.
结论:
- 在过敏敏感化期间吸入臭氧会通过促进T H17驱动的炎症反应加剧喘.
- 同时暴露于臭氧和HDM导致喘表型明显恶化.
- 这些发现强调了空气污染物对过敏呼吸道疾病的有害影响.
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