孕激素修饰的自然循环制剂用于冷胚胎移植
Nikolay Kornilov1, Alex Polyakov2, Anastasiya Mungalova3
1Centre for Reproductive Medicine, Co. Ltd., Next Generation Clinic, St Petersburg, Russia; Centre for Reproductive Medicine, Co. Ltd., Next Generation Clinic, Moscow, Russia.
Reproductive biomedicine online
|September 8, 2024
概括
孕激素修饰自然循环 (P4mNC) 和激素替代疗法 (HRT) 方案显示,冷胚胎移植 (FET) 的活产率相似. 这表明P4mNC提供了可比的结果,对生育治疗的时间更为灵活.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
背景情况:
- 子宫内膜的准备对于成功的冷胚胎移植 (FET) 是至关重要的.
- 激素替代疗法 (HRT) 是一种常见的方案,但孕激素修饰自然循环 (P4mNC) 提供了一个替代方案.
研究的目的:
- 为了比较P4mNC和HRT子宫内膜制备方案在单个欧普洛伊德母细胞细胞FET周期中的临床结果.
- 为了评估活产率,临床怀孕率和流产率.
主要方法:
- 723个FET周期的回顾性队列研究 (2017年1月至2019年12月).
- 327个P4mNC-FET周期和396个HRT-FET周期的比较.
- 分析初级 (活产率) 和二级 (临床怀孕,流产率) 结果.
主要成果:
- 在活产率 (45.0%对39.6%,P=0.331) 中没有观察到统计学意义上的差异.
- 经过调整后,临床怀孕率 (50.2%与47.0%,P=0.688) 和流产率 (9.8%与14.5%,P=0.115) 在组之间也相似.
结论:
- P4mNC-FET周期的临床结果与HRT-FET周期相似.
- P4mNC为HRT提供了可行的替代方案,提供了可比的疗效,在FET时间安排中提高了灵活性.
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