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Updated: Jun 14, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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揭示了新型的螺旋氧二醇结合的皮拉佐洛皮里丁衍生物的抗癌潜力

Wagdy M Eldehna1, Maha-Hamadien Abdulla2, Mohamed S Nafie3

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, P.O. Box 33516, Kafrelsheikh, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia St., Alexandria 21648, Egypt.

Bioorganic chemistry
|September 8, 2024
PubMed
概括

新型的螺旋indole-pyrazolo [3,4-b] 氨酸衍生物显示出强大的抗癌活性. 这些化合物有效地抑制癌细胞生长,并向具有低毒性的表皮生长因子受体 (EGFR) 激酶.

关键词:
生物评估生物评估.异氨酸 是一种异氨酸.激酶抑制剂 激酶抑制剂分子对接 分子对接胰腺癌是一种胰腺癌.皮肤癌 皮肤癌 皮肤癌综合合成 综合合成

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