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运动性认知风险综合征作为认知障碍和痴呆症的预测因素 - 一项系统性审查和元分析

Nicholas E-Kai Lim¹, Brian Sheng Yep Yeo¹, Rachel Siying Lee¹

¹Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Ageing research reviews

|September 8, 2024

概括

运动性认知风险综合征 (MCR) 显著增加认知障碍和痴呆的风险. 这种预测因素在对老年人的临床风险评估中需要考虑.

科学领域:

老年学是一门学科.
神经学神经学
流行病学流行病学

背景情况:

运动认知风险综合征 (MCR) 具有缓慢的步行速度和主观认知下降的特征,在没有移动障碍或痴呆症的老年人中.
MCR与发展认知障碍和痴呆症的风险之间的关联仍在争论中.
本研究旨在综合有关MCR与认知衰退联系的现有证据.

研究的目的:

为了全面总结和综合关于运动认知风险综合征 (MCR) 与认知障碍/痴呆症之间的关联的证据.
评估MCR对长期认知结果的预测价值.

主要方法:

在PubMed,Embase和Cochrane图书馆进行系统的文献搜索,截至2024年8月19日.
包括观察性和随机化研究,有利于最大限度调整的风险估计.
17项研究 (1,206,782名参与者) 的分析,对异质性,敏感性和子组进行分析.

主要成果:

与对照组相比,MCR患者的认知障碍和痴呆风险增加了2.20倍 (RR=2.20;95% CI=1.91-2.53).
结果在各个子组和灵敏度分析中是一致的,表明了强度.
没有发现显著的出版偏差.

结论:

运动性认知风险综合征 (MCR) 可能成为长期认知障碍和痴呆症的重要预测因素.
对认知能力下降风险的临床评估应考虑MCR.
需要进一步的研究才能充分阐明MCR与痴呆症的关联.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的疾病.认知能力下降认知能力下降认知障碍认知障碍是一种认知障碍.痴呆症是一种痴呆症.运动认知风险综合征

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