构成,优化和评估ibuprofen装载的薄荷体,用于通过皮肤输送
Devika Nayak1, Manisha M Shetty1, Praveen Halagali1
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
International journal of pharmaceutics
|September 8, 2024
概括
这项研究开发了优化的薄荷体,以增强皮下输送布洛芬 (IBU). 薄荷体在老鼠模型中显示出改善的皮肤透性和显著的抗炎和止痛作用.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 通过皮肤输送的药物提供优势,而不是口服的非类固醇抗炎药物 (NSAIDs).
- 开发有效的囊泡载体对于增强皮肤透性可溶性较差的药物,如布洛芬 (IBU) 的提高至关重要.
- 薄膜体代表了一种新的囊泡系统,有可能改善药物封装和释放.
研究的目的:
- 制定和优化含有布洛芬的薄荷体,以提高通过皮肤透的效果.
- 评估优化IBU-menthosomes的体外,体外和体内表现.
- 评估开发的薄荷体配方的抗炎和止痛潜力.
主要方法:
- 用薄膜水化方法制备了含有布洛芬的薄膜分子.
- 使用2 ^ 3因数设计优化配方,以囊泡大小,多分散度指数和捕获效率作为关键参数.
- 使用老鼠皮肤进行了体外和体外皮肤透研究,并在卡拉根诱导的脚胀和甲试验模型中进行了体内药学动力学评估.
主要成果:
- 优化的IBU-menthosomes实现了囊泡大小为214.2nm,PDI为0.267,捕获效率为78.7%.
- 与传统的脂质体相比,观察到显著增强的体外 (77.02%) 和体外 (40.91%) 皮肤透率.
- 该配方在老鼠模型中表现出优异的抗炎活性 (p < 0.01) 和显著的止痛作用 (p < 0.05).
结论:
- 优化的布洛芬载满薄荷体有效地增强了通过皮肤递送药物的效果.
- 薄膜体作为一个有前途的囊泡载体,通过透皮途径提高NSAIDs的治疗疗效.
- 这种方法有可能通过皮肤输送其他NSAID药物.
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