使用aptamer控制的刺激反应药物释放
Xingxing Peng1, Yanfei Liu2, Feicheng Peng3
1Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan Province, PR China.
International journal of biological macromolecules
|September 8, 2024
概括
阿普塔默为刺激响应药物输送系统提供可编程控制. 本综述详细介绍了aptamer机制,组装策略和针对药物释放的应用,解决挑战和未来方向.
科学领域:
- 生物医学工程 生物医学工程
- 纳米医学是一种纳米医学.
- 药物输送系统 药物输送系统
背景情况:
- 在纳米医学中,aptamers越来越多地被利用,因为它们具有独特的可编程,可激活和可切换特性.
- 响应刺激的药物输送系统提供有针对性和受控的治疗释放.
- 目前还没有对受体控制的刺激反应药物输送进行全面的审查.
研究的目的:
- 强调在构建刺激响应药物递送系统时使用aptamer的机制和优势.
- 总结阿普坦酶组装/重新配置机制和药物释放策略.
- 详细阐述基于aptamer的刺激反应药物释放的应用,挑战和未来方向.
主要方法:
- 对基于aptamer的药物输送现有文献的审查.
- 分析受各种刺激 (例如,pH,光,温度,链位移) 影响的阿普坦酶结合机制.
- 在阿普他默介导系统中的组装和药物释放策略的说明.
主要成果:
- 可以有效地组装和重新配置aptamers以控制药物释放以应对特定的刺激.
- 阐明了对体对目标的刺激反应性结合机制,以及它们因环境因素的调制.
- 介绍了基于aptamer的系统用于有针对性和受控的药物释放的各种应用.
结论:
- 胺剂是开发先进刺激响应药物递送平台的多功能工具.
- 了解aptamer刺激相互作用对于优化药物释放概况至关重要.
- 需要进一步的研究来克服当前的挑战,并充分实现基于aptamer的纳米医学的潜力.
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