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相关概念视频

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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使用aptamer控制的刺激反应药物释放.

Xingxing Peng1, Yanfei Liu2, Feicheng Peng3

  • 1Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan Province, PR China.

International journal of biological macromolecules
|September 8, 2024
PubMed
概括
此摘要是机器生成的。

阿普塔默为刺激响应药物输送系统提供可编程控制. 本综述详细介绍了aptamer机制,组装策略和针对药物释放的应用,解决挑战和未来方向.

关键词:
应用程序 应用程序药物释放控制的aptamer控制的药物释放.组装/重新配置机制.药物释放是响应刺激的药物.

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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米医学是一种纳米医学.
  • 药物输送系统 药物输送系统

背景情况:

  • 在纳米医学中,aptamers越来越多地被利用,因为它们具有独特的可编程,可激活和可切换特性.
  • 响应刺激的药物输送系统提供有针对性和受控的治疗释放.
  • 目前还没有对受体控制的刺激反应药物输送进行全面的审查.

研究的目的:

  • 强调在构建刺激响应药物递送系统时使用aptamer的机制和优势.
  • 总结阿普坦酶组装/重新配置机制和药物释放策略.
  • 详细阐述基于aptamer的刺激反应药物释放的应用,挑战和未来方向.

主要方法:

  • 对基于aptamer的药物输送现有文献的审查.
  • 分析受各种刺激 (例如,pH,光,温度,链位移) 影响的阿普坦酶结合机制.
  • 在阿普他默介导系统中的组装和药物释放策略的说明.

主要成果:

  • 可以有效地组装和重新配置aptamers以控制药物释放以应对特定的刺激.
  • 阐明了对体对目标的刺激反应性结合机制,以及它们因环境因素的调制.
  • 介绍了基于aptamer的系统用于有针对性和受控的药物释放的各种应用.

结论:

  • 胺剂是开发先进刺激响应药物递送平台的多功能工具.
  • 了解aptamer刺激相互作用对于优化药物释放概况至关重要.
  • 需要进一步的研究来克服当前的挑战,并充分实现基于aptamer的纳米医学的潜力.