易于注射的凝-非纳纳尔水凝,用于肠胃多的内切除
Harshil Dave1, Hitasha Vithalani1, Hemant Singh2
1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gujarat, India.
International journal of biological macromolecules
|September 8, 2024
概括
一种新的可注射水凝改善了胃肠道片切除的粘膜下注射. 这种基于凝的剪切稀释液提供了稳定的缓冲和增强的安全性,用于早期清除聚合物.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 聚合物化学 聚合物化学
背景情况:
- 粘膜下注射对于胃肠道聚切除至关重要.
- 现有的水凝经常面临诸如快速凝和注射堵塞等挑战.
- 自然的多衍生水凝显示出有前途,但需要改进配方.
研究的目的:
- 开发一种新型的可注射,剪切稀释水凝,用于胃肠道聚切除中的下注射.
- 为了评估修改过的凝水凝的物理化学特性和性能.
- 在ex vivo和in vivo模型中评估水凝的生物相容性和有效性.
主要方法:
- 从非门修饰的凝聚合物合成了一种新的剪切稀释水凝.
- 典型的水凝特性:剪切薄化,自组装,染料封装,流量,稳定性和注射性.
- 对山羊肠进行了ex vivo研究,以评估形成和寿命.
- 评估血液凝固时间和血液相容性 (血液溶解).
- 使用HepG2和nHDF细胞进行了体外生物相容性评估.
- 在小鼠身上进行了体内研究,以确定生物相容性,器官毒性和枕头高度.
主要成果:
- 开发的水凝具有出色的剪切稀释性能,可通过各种针尺 (18-24G) 进行有效的注射.
- 活体研究表明,形成了稳定的,可见的下粘膜 (大约2~3cm). 8.07毫米) 持续时间长达60分钟.
- 水凝显示出快速的血液凝固 (大约. 120秒) 的时间,血液溶解最小 (3.77%).
- 实验室和体内研究证实了小鼠的理想生物相容性,无毒器官概况和最佳高度.
结论:
- 这种新型的非门修饰的凝水凝是一种有前途的候选人,用于胃肠道片切除的下注射.
- 它独特的剪切稀释性质和稳定的缓冲形成增强了下膜的升高,改善了多片的去除.
- 水凝的有利血红相容性和生物相容性支持其在胃肠道程序中的临床应用潜力.
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