对P2Y12抑制剂反应的遗传决定因素和临床影响

Larisa H Cavallari1, James C Coons2

  • 1Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Precision Medicine, University of Florida, 1333 Center Drive, PO Box 100486, Gainesville, FL 32610, USA.

PubMed
概括

在CYP2C19的遗传变异影响克洛皮多格雷尔的激活,减少约30%的人的有效性. 对于这些遗传变异的个体,建议使用普拉苏格勒或提卡格勒尔等替代药物.

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