使用无冲洗方法刷后化物的动力学
Tipparat Parakaw1, Sirada Srihirun1, Pornpen Dararat1
1Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
BMC oral health
|September 8, 2024
概括
无冲洗刷方法可以增加口服化物保留时间长达30分钟,而不会影响全身化物吸收或毒性. 这一发现支持其提高牙腐烂预防的潜力.
科学领域:
- 口腔健康研究 口腔健康研究
- 牙科药理学 牙科药理学
- 化物的动力学
背景情况:
- 化物对于预防牙损伤和改善口腔卫生至关重要.
- 无冲洗刷方法旨在最大限度地保持口腔中的化物.
- 对于无冲洗方法的安全性和有效性存在担忧.
研究的目的:
- 用无冲洗刷方法研究口服化物吸收的动力学.
- 评估与无冲刷刷技术相关的潜在系统风险.
- 为了比较无冲洗和传统冲洗方法之间的化物保留.
主要方法:
- 一项涉及十名健康成年人的交叉研究,比较无冲洗和冲洗刷方法.
- 随着时间的推移,测量唾液 (超级和沉积物) 和尿液中的化物水平.
- 血中化物含量和药物动力学参数的分析.
主要成果:
- 没有冲洗的方法导致唾液上游物中的化物水平立即和持续上升,长达30分钟.
- 在没有冲洗的方法下,液中化物总度持续高达5分钟.
- 通过血液和尿液分析,两种方法之间没有观察到系统化物吸收的显著差异.
结论:
- 无冲洗刷方法有效地提高了口服化物保留时间.
- 这种方法似乎不会显著增加系统化物水平,也不会带来毒性风险.
- 这些发现支持无冲洗方法作为改善口服化物暴露的安全有效策略.
相关概念视频
Calculating pH Changes in a Buffer Solution
53.0K
A buffer can prevent a sudden drop or increase in the pH of a solution after the addition of a strong acid or base up to its buffering capacity; however, such addition of a strong acid or base does result in the slight pH change of the solution. The small pH change can be calculated by determining the resulting change in the concentration of buffer components, i.e., a weak acid and its conjugate base or vice versa. The concentrations obtained using these stoichiometric calculations can be used...
53.0K
Solubility Equilibria: Overview
621
When a substance such as sodium chloride is added to water, it dissolves, forming an aqueous solution. The extent of dissolution is called solubility. The process of dissolution can exist in equilibrium, just like other chemical processes. Solubility equilibria are also called precipitation equilibria because the process of solubility can be reversible. The reverse of the solubility process is called precipitation.
Solubility is important in biological and environmental processes. A notable...
Solubility is important in biological and environmental processes. A notable...
621
Precipitation Reactions
50.3K
In a precipitation reaction, aqueous solutions of soluble salts react to give an insoluble ionic compound – the precipitate. The reaction occurs when oppositely charged ions in solution overcome their attraction for water and bind to each other, forming a precipitate that separates out from the solution. Since such reactions involve the exchange of ions between ionic compounds in aqueous solution, they are also referred to as double displacement, double replacement, exchange reactions, or...
50.3K


