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利用多种细胞应激模式来预测多发性骨髓瘤患者的临床结果和治疗反应

Jiaxuan Xu¹, Xiaoqing Dong¹, Jiahui Dong¹

¹Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, China-Australia Institute of Translational Medicine, School of Life Sciences, Nanjing University, Nanjing, China.

Journal of cellular and molecular medicine

|September 8, 2024

概括

一个新的细胞压力指数 (CSI) 模型预测了多发性骨髓瘤 (MM) 患者的预后和治疗反应. 高CSI与糟糕的结果相关,但对某些疗法的敏感性,有助于个性化风险分层.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

多发性骨髓瘤 (MM) 的瘤微环境具有影响疾病进展的压力因素.
细胞应激在MM患者预后和治疗反应中的作用尚不清楚.

研究的目的:

开发一个全面的细胞应激指数 (CSI) 用于MM的生存和治疗预测.
调查CSI与临床特征,免疫微环境和治疗敏感性的关联.

主要方法:

整合了五种压力模式 (热量,氧化,缺氧,基因毒性,ER) 来创建一个CSI.
开发了一个使用考克斯回归的九基因CSI签名,并在三个数据集中验证了它.
执行共识聚类以根据CSI基因配置文件识别分子亚型.
构建并验证了一个结合CSI的预后名录.

主要成果:

高CSI与细胞分裂途径和较差的临床预后相关.
确定了两种不同的MM亚型,具有显著的预后差异.
基于CSI的诺米图表显示出强大的预测性能.
与免疫细胞透和免疫检查点基因表达相关的CSI.
高CSI表明对博尔特佐米布和抗菌素剂的敏感性,但免疫疗法反应不那么有利.

结论:

CSI签名作为MM评估的临床适用指标.
在预测MM患者的预后和指导个性化治疗方面,CSI具有潜力.

关键词:

细胞应激指数是指细胞应激指数.多发性骨髓瘤是多发性骨髓瘤的一种.命名图形模型命名图形模型治疗敏感性的治疗敏感性.瘤微环境是一个微环境.

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