与健康成年人的参考材料相比,COVID-19后的最大呼吸压力:一个前性队列研究 (SECURe研究)
Thora Wesenberg Helt1, Jan Christensen2, Ronan M G Berg1,3,4
1Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Physiological reports
|September 8, 2024
概括
在COVID-19后5个月,很少有人经历最大吸气压 (MIP) 和最大呼气压 (MEP) 的降低,在12个月后观察到的改善最小. 这项研究评估了各种COVID-19疾病严重程度的呼吸道肌肉力量.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 长期呼吸道症状,包括肺功能减弱 (最大吸入压力-MIP和最大呼气压力-MEP),在COVID-19后报告.
- 之前对COVID-19后MIP和MEP的研究缺乏方法的标准化,并且没有全面评估所有疾病严重程度组.
研究的目的:
- 在不同疾病严重程度的COVID-19感染后的个体中确定最大吸气压 (MIP) 和最大呼气压 (MEP).
- 使用标准化方法建立参考值,与COVID-19幸存者进行比较.
- 评估降低MIP和MEP随着时间的推移而持续的持续性.
主要方法:
- 一组145名COVID-19患者 (2020年3月至2021年3月) 使用microRPM测量了MIP和MEP.
- 在298名健康成年人中,使用相同的标准化微RPM方法确定了参考值.
- 随访测量是在诊断后5个月的中位数和12个月后再次进行的.
主要成果:
- 16%的参与者在COVID-19后5个月出现了降低的MIP和/或MEP.
- 降低MIP/MEP的个体表现出螺旋计和肺总容量下降,但扩散能力没有下降.
- 在5个月后呼吸肌力减弱的患者中,80%的患者在12个月后仍然有减弱的力量.
结论:
- 在COVID-19后5个月的少数个体中,最大吸气压 (MIP) 和最大呼气压 (MEP) 的降低存在.
- 在感染后5至12个月之间观察到MIP和MEP的有限改善.
- 标准化的呼吸肌肉强度测量对于了解长期COVID-19呼吸系统后果至关重要.
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