胃肠道表现的患病率和结果在澳大利亚硬化皮肤症队列中
Alannah Quinlivan1, Dylan Hansen2, Wendy Stevens2
1St. Vincent's Hospital Melbourne, Fitzroy, and The University of Melbourne, Melbourne, Victoria, Australia.
Arthritis care & research
|September 9, 2024
概括
胃肠道症状在全身性硬化症 (SSc) 中很常见,严重影响生活质量和身体功能. 然而,这些症状似乎不会增加SSc患者的死亡风险.
科学领域:
- 类风湿病学 类风湿病学
- 胃肠病学 胃肠病学
- 临床医学 临床医学
背景情况:
- 系统性硬化症 (SSc) 经常影响胃肠道 (GIT).
- 了解GIT症状的流行和影响对于管理SSc患者至关重要.
研究的目的:
- 为了确定SSc患者中GIT症状的患病率.
- 评估GIT症状对生存,身体功能,生活质量 (QoL),情绪,疲劳和就业的影响.
主要方法:
- 利用了907名SSc患者在澳大利亚硬化硬质皮症队列研究中的数据.
- 在加利福尼亚大学洛杉矶分校工作,用于评估症状的硬化皮肤临床试验联盟胃肠道2.0问卷 (UCLA GIT).
- 应用多变量通用估计方程 (GEE) 和考克斯比例危险回归模型来分析关联.
主要成果:
- 87%的SSc患者报告了GIT症状;46-52%的患者经历了中度至严重的反流,膨胀,腹或便秘.
- 较高的UCLA GIT分数与较差的QOL,身体功能,增加的疲劳,焦虑和抑郁相关.
- 严重的GIT症状与失业有关,但与死亡率没有独立关联.
结论:
- 胃肠道表现在SSc中非常普遍.
- 关节炎症的症状显著损害了生活质量,身体功能和就业状态.
- 在SSc中GIT症状不是增加死亡率的直接预测因素.
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