细胞巨病毒免疫反应与血清NfL较低和多发性硬化症发病时残疾累积风险相关
Jan D Lünemann1, Augusto Sao Avilés2, Mar Tintoré2
1Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
概括
对人类细胞巨化病毒 (HCMV) 的高免疫反应可以防止多发性硬化症 (MS) 的进展. 这表明,在多发性硬化症患者中,HCMV感染具有潜在的保护作用,减少中枢神经系统损伤.
科学领域:
- 神经免疫学 神经免疫学
- 病毒免疫学 病毒免疫学
背景情况:
- 人类细胞巨化病毒 (HCMV) 和爱斯坦-巴尔病毒 (EBV) 感染与多发性硬化症 (MS) 的预后有关.
- 了解病毒免疫反应和MS进展之间的关系对于开发向疗法至关重要.
研究的目的:
- 研究在疾病发作时对HCMV和EBV的幽默免疫反应与血清和脑脊液 (CSF) 生物标志物的变化之间的关联.
- 确定这些病毒性免疫反应是否与MS患者的炎症和神经退行性标志物相关.
主要方法:
- 分析了98名多发性硬化患者的队列,平均随访时间为20年.
- 血清和脑脊液样本是在第一个脱髓化事件发生时采集的.
- 测量了9种生物标志物的水平,以及对HCMV和EBV抗原的免疫反应.
主要成果:
- 对HCMV的强免疫反应与血清神经丝光链 (sNfL) 水平相反相关,这是神经退行症的标志物.
- 升高的sNfL水平与增加的残疾和更高的二次进展性MS的风险有关.
- 在患有对EBV核抗原1的高免疫反应的患者中观察到血清中可溶性CD21水平的增加.
结论:
- 对HCMV的强有力的免疫反应与MS中疾病进展和中枢神经系统 (CNS) 损伤的减少有关.
- 这些发现支持HCMV感染在多发性硬化症的背景下具有潜在的保护作用.
- 对病毒与宿主相互作用的进一步研究可能会揭示MS的新疗法策略.
相关概念视频
Immunological Memory
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...


