选择性交叉链接的基于水凝的尾酒药物输送微芯片用于结肠癌组合药物查,使用AI-CSR平台用于精密医学
Kiran Kaladharan1, Chih-Hsuan Ouyang1, Hsin-Yu Yang1
1Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan, Republic of China. fangang@ess.nthu.edu.tw.
Lab on a chip
|September 9, 2024
概括
这项研究引入了一种新的水凝药物芯片,用于快速组合癌症治疗查. 该平台精确量化并释放药物组合,加速有效癌症治疗方法的识别.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 癌症是全球主要的死亡原因,推动了对先进治疗策略的需求.
- 组合药物治疗提供了增强的疗效,但需要精确控制药物的剂量和释放.
- 目前用于选药物组合的方法耗时且效率低下.
研究的目的:
- 开发一种基于水凝的平台,用于同时量化和释放用于癌症查的药物尾酒.
- 整合一个人工智能平台,以确定最佳的药物剂量组合.
- 展示一种更快,更精确,更有效的组合药物查方法.
主要方法:
- 在PDMS基板上制造了一个选择性交叉链接的水凝阵列,使用UV光电法.
- 抗癌药物尾酒被精确地装入并并行释放到HCT-116结肠癌细胞中.
- 基于人工智能的复杂系统响应 (AI-CSR) 平台被用于分析查结果.
主要成果:
- 该平台在短短两个半小时内成功选了155种药物剂量组合.
- 该系统表现出高效率,低药物消耗 (每片芯片补丁1μL).
- 使用AI-CSR平台确定了最佳的药物剂量组合.
结论:
- 开发的PDMS药物加载水凝平台为尾酒药物查提供了一种新且快速的方法.
- 这种方法显著提高了识别有效的癌症治疗组合的速度和精度.
- 该平台有望加速药物发现和个性化癌症治疗.
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