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与SARS-CoV-2信使RNA疫苗相关的肝损伤的组织学特征

Rebecca C Obeng^1,2,3, David J Escobar⁴, Brian Vadasz⁴

¹From the Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio (Obeng, Xue).

Archives of pathology & laboratory medicine

|September 9, 2024

概括

SARS-CoV-2 mRNA 疫苗很少引起肝损伤,通常呈现为中度至严重的活性肝炎. 大多数病例会自发或通过类固醇治疗缓解,尽管有些人可能会引发潜在的免疫条件.

科学领域:

肝病学肝病学是一种肝病学.
疫苗学疫苗学疫苗学
免疫学免疫学免疫学

背景情况:

药物诱导的肝损伤很常见,但疫苗诱导的肝损伤很少见.
广泛使用SARS-CoV-2信使RNA (mRNA) 疫苗导致有关肝损伤的报道.

研究的目的:

在SARS-CoV-2 mRNA疫苗接种后,描述肝损伤的组织学特征.

主要方法:

来自12名患者的13个肝脏活检的综述,其中12名患者的肝脏酶因SARS-CoV-2mRNA疫苗 (2021-2022) 而升高.
对人口统计,临床信息和活检结果的分析.

主要成果:

主导的组织学模式是中度至重度的活性肝炎 (69%).
大多数患者 (9/12) 在接种疫苗后2个月内出现症状;在9名患者中检测到自身免疫抗体.
所有患者都自发恢复或接受类固醇治疗,除了一个患有自身免疫性肝炎的患者.

结论:

与SARS-CoV-2mRNA疫苗相关的肝损伤通常呈现为中度至重度的活性肝炎.
女性患者可能更容易受到感染.
肝损伤通常会通过治疗而消失,但接种疫苗可以揭露潜在的免疫状况.

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