在非小细胞肺癌中进行外科免疫疗法
Renzhi Zhang1, Chun Zou2, Liang Zeng1,2
1Department of Medical Oncology, Graduate Collaborative Training Base of Hunan Cancer Hospital, Hengyang Medical School, University of South China, Hengyang.
Current opinion in oncology
|September 9, 2024
概括
术后免疫疗法,包括PD-1/PD-L1抑制剂,现在是可切除非小细胞肺癌 (NSCLC) II-III阶段的标准. 这种方法显著降低了复发风险,并改善了接受手术的患者的生存率.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胸部外科手术 胸部外科手术
背景情况:
- 非小细胞肺癌 (NSCLC) 治疗已经显著发展.
- 免疫检查点抑制剂 (ICI) 已成为一个关键的治疗类.
研究的目的:
- 审查NSCLC手术期间免疫疗法的当前临床疗效和安全性.
- 为了指导未来的治疗策略和个性化治疗,以改善患者的治疗结果.
- 总结NSCLC治疗选择的潜在生物标志物.
主要方法:
- 对最近的临床试验和文献进行系统审查.
- 对术后免疫疗法III期临床试验数据的分析.
- 对治疗模式和安全概况的评估.
主要成果:
- 术后免疫疗法,特别是PD-1/PD-L1抑制剂,已显著降低可切除NSCLC的术后复发风险.
- 作为治疗II至III期切除性NSCLC的新标准.
- 许多临床问题正在积极调查中,包括患者选择,治疗方案选择,治疗持续时间和病后完全反应 (pCR) 管理.
结论:
- 周围手术免疫疗法代表了NSCLC治疗的范式转变,特别是在可切除II-III阶段.
- 这种方法提供了实质性的生存益处,并已成为术后护理的既定标准.
- 目前正在进行的研究解决了关键的临床问题,以优化在术后免疫疗法时代的患者管理.
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