具有可重编程药物分配功能的磁性微型软机器人:朝着先进的有针对性的组合疗法发展
Zilin Yang1, Changyu Xu1, Jia Xin Lee2
1School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Advanced materials (Deerfield Beach, Fla.)
|September 9, 2024
概括
一个新的毫米级软机器人可以精确地在向组合治疗中输送四种药物. 这种无绑定执行器提供可重编程的药物递送序列和剂量,用于先进的医疗治疗.
科学领域:
- 生物医学工程 生物医学工程
- 机器人技术 机器人技术 机器人技术
- 材料科学 材料科学 材料科学
背景情况:
- 微型机器人为有针对性的药物输送提供了潜力,提高了治疗效率并减少了并发症.
- 目前的微型机器人缺乏先进的向组合疗法的能力,因为它们受到药物容量,分发控制和多地点分发的限制.
- 现有的多药机器人无法调整药物序列,剂量或在多个位置选择性地分发药物.
研究的目的:
- 开发一个能够进行先进的向组合治疗的毫米级软机器人.
- 为了实现多种药物的精确,可编程的输送,可调节序列和剂量.
- 为了克服现有的微型机器人在药物输送精度和多功能性方面的局限性.
主要方法:
- 由交替磁场驱动的毫米级软机器人被设计和制造.
- 机器人被设计为六个自由度的运动,包括滚动和双爬.
- 配送四种类型的药物的能力与可重编程序列和剂量被整合.
主要成果:
- 软机器人成功地分发了四种类型的药物,并控制了剂量 (0.0992-0.231μL h-1).
- 机器人展示了精确的导航和药物输送到无结构环境中的多个站点.
- 在移动和处方期间观察到微不足道的药物泄漏,突出显示了其可靠性.
结论:
- 拟议的毫米尺度软机器人代表了微型机器人药物递送技术的重大进步.
- 这项技术使先进的有针对性的多种药物联合治疗具有前所未有的灵活性.
- 机器人的能力具有巨大的潜力,可以彻底改变个性化医疗和复杂的治疗策略.
相关概念视频
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