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端粒长度作为多发性硬化症中的生物标志物
Maria Agustina Piedrabuena1, Jorge Correale1,2,3, Mauricio Franco Farez4
1Departamento de Neurologia, Fleni, Buenos Aires, Argentina.
Multiple sclerosis (Houndmills, Basingstoke, England)
|September 9, 2024
概括
白细胞端粒长度 (LTL) 随着年龄的增长而缩短,并且与患有多发性硬化症 (MS) 的老年人残疾有关. 较年轻的MS患者中较短的LTL与疾病严重程度无关,这表明其他因素也参与其中.
科学领域:
- 神经免疫学 神经免疫学
- 衰老的研究研究.
- 多发性硬化症中的生物标志物
背景情况:
- 白血球端粒长度 (LTL) 是衰老的生物标志物,并与多发性硬化症 (MS) 病原发生有关.
- 了解LTL和MS进展之间的关系对于开发向疗法至关重要.
研究的目的:
- 调查LTL与MS年轻和老年个体的临床/放射性参数之间的关联.
- 测试这样的假设:患有多发性硬化和短LTL的年轻人表现出与老年多发性硬化患者类似的疾病特征.
主要方法:
- 一项长达2年的前性研究,涉及两组年轻人 (18-35岁) 和老年人 (≥50岁) 患有多发性硬化症 (pwMS).
- 评估包括身体和认知评估,3T脑MRI,视网膜神经纤维层 (RNFL) 测量和通过qPCR量化LTL.
- 记录了疾病持续时间,吸烟状态,残疾 (EDSS),神经功能 (9HPT) 和治疗疗效.
主要成果:
- 与年轻的pwMS相比,LTL在老年pwMS中较短,在男性与女性之间较短.
- 在老年人pwMS中,较短的LTL与更长的疾病持续时间,吸烟,更高的EDSS得分,在9HPT上的表现较差,使用高效疗法和增加的大脑损伤体积 (BLV) 相相关.
- 在年轻的pwMS中,LTL与临床或放射学变量没有相关性. 较短的LTL与灰色和白质体积的减少有关.
结论:
- 在患有MS的老年人中,LTL与残疾和脑损伤负担有关.
- 虽然 LTL 缩短是 pwMS 衰老的一个因素,但其他神经退行性机制可能会在这个人群中促进疾病的进展.
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