异环替代的阿里拉佐亚胺联体及其Cu (I) 协调复合体的结合机制和治疗活性
Laxmi Tiwari1, Caleb Leach2, Ashley Williams2
1Department of Chemistry, University of Idaho, Moscow, Idaho 83844, United States.
ACS omega
|September 9, 2024
概括
新的亚类型胺-铜 (I) 复合物显示出强大的抗癌和抗菌活性. 基于pyrrolidine的复合物表现出强大的结合和增强的生物效应,这表明有可能开发新药.
科学领域:
- 药用化学 医学化学
- 协调化学 协调化学
- 抗微生物和抗癌药物发现
背景情况:
- 目前正在寻找用于癌症和抗微生物疗法的新生物活性化合物.
- 亚类胺 (ATF) 是一种新型的化合物,能够合金属,形成稳定的协调复合物.
- 纳入异环基替代剂可以增强ATF的药物性质,用于生物评估.
研究的目的:
- 为了合成和表征新型的亚二甲胺胺 (ATF) 连接物与各种异环替代剂.
- 为了与这些ATF连接体形成稳定的铜 (I) (Cu) 协调复合体.
- 评估合成的ATF-Cu (I) 复合物的抗微生物和抗癌活性.
主要方法:
- 使用pyrrolidine,piperidine,N-methylpiperazine和morpholine替代物的ATF配体的合成.
- 复合ATF连接物与各种Cu (I) 盐的复合.
- 使用紫外线定位和DFT计算 (B3LYP) 确定约束关联常数.
- 针对黄金葡萄球菌,大肠杆菌和白菌的抗菌检测.
- 针对人类癌细胞系 (A-549,K-562,HT-1080,MDA-MB-231) 和正常细胞系 (MRC-5,HFF) 的抗增殖试验.
主要成果:
- 与较大的异环环相比,皮罗利丁功能化的ATF与Cu (I) 盐 (10^4 - 10^5 M^-1) 的结合更强.
- 单独ATF配体的活性有限,除了对抗K-562细胞.
- 大多数ATF-Cu(I) 复合体对Candida albicans和黄金葡萄球菌具有低至中等的微分子活性.
- 几种ATF-Cu(I) 复合体对HT-1080纤维肉瘤细胞系 (亚微分子IC50值) 显示出显著的抗增殖活性.
- 较高的结合关联常数与增加的生物活性相关.
结论:
- 亚甲胺-铜 (I) 复合物显示出有前途的抗微生物和抗癌潜力.
- 在ATF连接体上的罗利丁替代剂增强了结合亲和力和生物活性.
- 这项研究突出了金属连接体结合强度和复合物的观察到的生物活性之间的相关性.
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