与伏利康纳血度相关的因素:系统性审查和元分析
Xiaoqi Li1, Qiaozhi Hu1, Ting Xu1
1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in pharmacology
|September 9, 2024
概括
只有大约一半的患者在没有剂量调整的情况下达到治疗性沃里可纳水平. 成年人的治疗度比儿童高,这突显了治疗药物监测的必要性,特别是在儿科患者中.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 药物新陈代谢 药物新陈代谢
背景情况:
- 伏利康纳的血度显示出显著的变化,影响治疗疗效.
- 维护voriconazole在治疗范围内的治疗对于最佳结果至关重要.
- 识别影响伏利康纳水平的因素对于个性化治疗至关重要.
研究的目的:
- 系统地审查和元分析达到治疗性伏利康纳血度的患者的患病率.
- 确定与达到治疗性伏利康纳的血度相关的因素.
- 为了比较成人和儿科患者之间的患病率.
主要方法:
- 从PubMed,Embase,Cochrane图书馆和Web of Science的研究进行系统审查和元分析,直到2023年11月.
- 随机效应模型用于汇集流行数据.
- 从包括的研究中总结的与沃里可纳度相关的因素.
主要成果:
- 在没有剂量调整的研究中,实现治疗性沃里康纳范围的综合流行率为56% (95% CI: 50%-63%).
- 成年人 (61%) 的综合患病率高于儿童 (55%).
- 影响伏利康纳水平的因素包括儿童的年龄和专蛋白,以及成年人同时服用的药物 (欧美,潘托普拉,甲基prednisolone,德克萨米他).
结论:
- 大约一半的患者在没有剂量调整的情况下无法达到治疗性沃里康纳水平.
- 成年人比儿童更容易达到治疗性沃里康纳的度.
- 治疗药物监测对于伏利康纳至关重要,特别是在儿科患者中,考虑到已确定的影响因素.
相关概念视频
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