流感病毒传播和症状:多季度家庭传播研究的动态和影响
Sinead E Morris1,2, Huong Q Nguyen3, Carlos G Grijalva4
1Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
PNAS nexus
|September 9, 2024
概括
了解流感病毒流失和症状时间是有效隔离策略的关键. 大多数人在症状出现之前就流失了病毒,隔离后的流失有所不同,影响了传播控制.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 通过隔离有症状的个体来减少流感的传播.
- 无症状的病毒泄漏仍然是控制传播的挑战.
- 有效的隔离需要了解流感病毒泄露和症状呈现之间的关系.
研究的目的:
- 为了研究流感病毒流失和症状呈现之间的相互作用.
- 量化症状前和隔离后的脱落,以告知隔离策略.
- 分析不同年龄组和疫苗接种情况的流产模式.
主要方法:
- 从2017年到2020年进行了一项经过案例确定的家庭传播研究.
- 在鼻上使用实时RT-qPCR量化了流感病毒的流失.
- 症状日记追踪了类似流感的疾病 (ILI) 症状,并使用混合效应模型进行分析.
主要成果:
- 5岁以下的儿童表现出更高的峰值流产,更长的流产持续时间,以及更严重的ILI症状.
- 大多数人 (63/105) 在症状出现之前,他们的病毒总量少于10%.
- 隔离后的脱落表现出基于个体因素,隔离终点和传染性假设的显著变化.
结论:
- 症状前的脱落是相当大的,仅仅基于症状发作的隔离的有效性受到限制.
- 隔离后脱落的变化凸显了个性化或适应性隔离策略的需要.
- 这些发现可以指导开发更有效的公共卫生干预措施,以减少流感传播.
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