脑线粒体损伤减弱由奎尔素和N-乙囊:外周和中心的抗效应
Sajad Abolfazli1, Sarvenaz Foroumand2, Elham Mohammadi2
1Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Mazandaran Province, Farah Abad Road, P3MV+78R. PO Box- 48175/861, Sari, Iran.
Toxicology research
|September 9, 2024
概括
奎尔赛丁 (QU) 和N-乙半氨酸 (NAC) 显示出作为恶心的天然疗法,减少吐和保护大脑免受氧化损伤的承诺. 它们的联合使用在本研究中被证明是最有效的.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 生物化学 生化学
背景情况:
- 恶心是一种保护性反射,但抗恶心药物有副作用,引发了对天然替代品的兴趣.
- 氧化压力在恶心引起的脑损伤中起着作用,这突显了神经保护策略的必要性.
- 奎尔塞丁 (QU) 和N-乙半氨酸 (NAC) 是天然的抗氧化剂,具有潜在的治疗益处.
研究的目的:
- 研究QU和NAC对恶心诱导的氧化损伤的抗和神经保护作用.
- 评估QU和NAC的疗效,单独和组合,在模型的吐.
- 评估QU和NAC对大脑线粒体中关键氧化应激生物标志物的影响.
主要方法:
- 在使用伊佩卡和硫酸铜的中诱导了.
- 动物接受了不同剂量的QU,NAC,它们的组合或美托克洛普拉米德 (MET) 的治疗.
- 分析了大脑线粒体的氧化损伤标记 (LPO,PC,ROS) 和功能 (线粒体功能,GSH水平).
主要成果:
- QU和NAC都显著减少了硫酸铜和伊佩卡引起的吐 (P<0.001).
- QU和NAC的使用降低了脂质过氧化 (LPO),活性氧物种 (ROS) 和蛋白质碳基 (PC) 的水平.
- 在QU和NAC治疗后,线粒体功能和谷氨 (GSH) 水平显著增加,组合治疗显示出最佳结果.
结论:
- 奎尔赛丁 (QU) 和N-乙半氨酸 (NAC) 具有显著的抗emetic特性,通过外周和中央机制起作用.
- 这些天然化合物提供神经保护,防止与吐相关的氧化性脑损伤.
- 与QU和NAC的联合治疗提供了增强的治疗效益,表明一种有希望的自然方法来控制恶心和相关的神经毒性.
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