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在盆腔放射治疗后,泌尿器官功能障碍和病理生理变化的临床前女性模型
Bethlehem Peters1, Shelby A Powers2,1, Lindsey K Burleson3,1
1Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, USA.
Cureus
|September 9, 2024
概括
盆腔放射治疗 (RT) 可以导致性和尿路功能障碍. 这项研究建立了一个大鼠模型来研究RT诱导的骨盆器官损伤的病理机制,揭示了生理学和形态学的时间变化.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生殖医学 生殖医学
背景情况:
- 盆腔放射治疗 (RT) 是盆腔癌的标准治疗方法,可以提高生存率.
- 然而,RT往往导致严重的性功能障碍和尿失禁.
- 这些副作用背后的精确病理机制和相关的临床前模型都缺乏.
研究的目的:
- 描述盆腔RT对雌性大鼠膀,阴道和尿道功能和结构的早期和晚期影响.
- 建立一个新的临床前模型来研究RT诱导的骨盆器官功能障碍.
主要方法:
- 雌性Sprague-Dawley大鼠接受一次20 Gy剂的盆腔RT或假治疗.
- 生理学评估包括阴道血液流动,阴道和道收缩性以及在RT后4周和9周的氧化应激标志物的基因表达.
- 形态分析包括评估纤维化和上皮质厚度.
主要成果:
- 在4周后,RT降低了阴道血流,在9周后恢复.
- 阴道收缩性和外部尿道神经性收缩在RT后增加.
- 膀神经性收缩减少,而阴道上皮质厚度减少,炎症标志物增加.
结论:
- 这种临床前模型阐明了RT诱导的性和泌尿功能障碍的时间病理生理学.
- 了解这些机制对于开发治疗策略来减轻癌症幸存者的RT副作用至关重要.
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