与empagliflozin相关的优糖性糖尿病酸性脂肪酸症被尿路感染掩盖
Sukhjinder Chauhan1, Victoria Diaz1, Ikechukwu R Ogbu2
1Internal Medicine, Mountainview Hospital, Las Vegas, USA.
Cureus
|September 9, 2024
概括
-葡萄糖共载体2 (SGLT2) 抑制剂有助于慢性病和心力衰竭患者. 这一案例突出了罕见但严重的euglycemic糖尿病酸症 (euDKA) 风险,强调了及时诊断和管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- -葡萄糖共载体2 (SGLT2) 抑制剂在治疗2型糖尿病 (T2DM),慢性病 (CKD) 和充血性心力衰竭 (CHF) 中有效.
- 这些药物可以降低心血管和整体死亡率,但会带来不良事件的风险,如euglycemic糖尿病酸症 (euDKA),尿路感染 (UTI) 和真菌感染.
研究的目的:
- 报告患者在接受SGLT2抑制剂治疗时同时出现eudka和尿路感染的病例.
- 要强调早期识别和管理SGLT2抑制剂相关的eudka的重要性.
主要方法:
- 病例报告详细介绍了90岁男性缺血性心肌病和T2DM的临床表现,诊断工作和治疗.
- 审查患者的病史,药物治疗方案 (包括SGLT2抑制剂) 和事件期间的实验室发现.
主要成果:
- 在接受SGLT2抑制剂治疗期间,患者出现了eudka和尿路感染.
- 立即停止使用SGLT2抑制剂并开始胰岛素输液治疗,导致危及生命的eudka.
结论:
- 尽管SGLT2抑制剂有好处,但即使没有严重的高血糖症,也可能导致eudka等严重并发症.
- 在服用SGLT2抑制剂的患者中对eudka的警,特别是那些同时感染或其他压力因素的患者,对于及时干预和改善结果至关重要.
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