经产期的环境风险对乙性食道炎:一个系统性审查和元分析.
Nicha Wongjarupong1, Malique Delbrune2, Busara Songtanin3
1Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, USA.
Cureus
|September 9, 2024
概括
这项元分析发现,抗生素使用,剖腹产,早产和NICU停留等早期生活因素之间存在微弱的关联,以及患有eosinophilic oesophagitis (EOE) 的风险增加. 需要进一步的研究来证实这些潜在的联系.
科学领域:
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
- 环境健康 环境健康
背景情况:
- 性食道炎 (EoE) 是食道的过敏性炎症性疾病.
- 关于EoE与环境风险因素之间的关联存在有限的数据.
- 围产期因素是对EdE发展的潜在环境影响.
研究的目的:
- 为了确定围产期风险因素和eosinophilic食道炎 (EOE) 之间的潜在关联.
- 通过对相关研究进行元分析,综合现有证据.
主要方法:
- 在MEDLINE,EMBASE,Scopus,Web of Science和Cochrane数据库中进行系统的文献搜索,截至2023年12月12日.
- 包括病例控制或队列研究,评估生命第一年内的围产期环境因素及其与EoE的关联.
- 使用随机效应模型进行元分析,以估计95%置信区间 (CI) 的聚合风险比率 (RR).
主要成果:
- 分析了六项研究 (2087例EoE,6786例对照).
- 与婴儿使用抗生素 (RR 1.30,95% CI: 1.11-1.52),剖腹产 (RR 1.22,95% CI: 1.10-1.34),早产 (RR 1.52,95% CI: 1.14-2.04) 和急症监护室入院 (RR 1.75,95% CI: 1.41-2.18) 相关的EoE风险增加.
- 没有发现与母乳养有显著关联 (RR 1.07,95% CI: 1.00-1.15).
- 检测到针对抗生素使用和剖腹产的出版偏差.
结论:
- 某些围产期因素 (抗生素使用,剖腹产,早产,新生儿重症监护室入院) 与EoE风险增加之间存在微弱的关联.
- 这些关联可能是间接的,而不是因果的.
- 需要进一步的研究来阐明这些围产期因素与 EoE 发育之间的关系.
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