评估由形束计算机断层扫描在各种视野中的X射线暴露引起的基因毒性和细胞毒性
Chintha Vishwadha1, Janumpally Varshitha Thanmai2, G Ramlal1
1Department of Oral Medicine and Radiology, SVS Institute of Dental Sciences, Mahabubnagar, IND.
Cureus
|September 9, 2024
概括
圆束计算机断层扫描 (CBCT) X射线增加了口腔细胞中的DNA损伤和细胞异常. 在CBCT扫描中,更大的视野 (FOV) 与更大的辐射诱导损伤有关,表明需要谨慎的剂量管理.
科学领域:
- 口腔医学是指口腔医学.
- 放射学 放射学是一门学科.
- 遗传学 是一个遗传学.
背景情况:
- 圆束计算断层扫描 (CBCT) 提供了牙的好处,但涉及X射线暴露.
- 即使是低剂量的X射线也可能导致细胞毒性作用,DNA损伤和核变化.
研究的目的:
- 评估CBCT扫描中的X射线的基因毒性和细胞毒性.
- 根据不同的视野 (FOV) 在脱皮的口腔粘膜细胞中评估这些效应.
主要方法:
- 选择了66名接受CBCT的患者.
- 皮细胞学被用来收集口腔粘膜细胞.
- 显微镜检查发现了核和细胞学异常.
主要成果:
- 在CBCT暴露后的所有患者群体中观察到微核的显著增加.
- 在所有FOVs的辐射暴露后,卡里奥雷克西斯也增加了.
- 在最大的FOV群体中发现了暴露和卡里奥雷克西斯之间的显著联系.
结论:
- 暴露于CBCT辐射显著增加了口腔细胞中的微核和卡里奥雷克斯.
- 细胞损伤的程度与视野大小相关.
- 在CBCT程序中,辐射剂量优化至关重要.
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