在以乙醇为基础的手部消毒剂中确定挥发性杂质和乙醇含量:符合性和毒性
Yolande Saab1, Rebecca Zgheib1, Zahi Nakad2
1Pharmaceutical Sciences Department, School of Pharmacy, Lebanese American University, Lebanon.
Toxicology reports
|September 9, 2024
概括
许多手部消毒剂含有有害杂质,如和不足的乙醇. 消费者应该意识到,某些产品可能是无效的,并且由于污染而对健康构成风险.
科学领域:
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 以乙醇为基础的手部消毒剂对于感染控制至关重要.
- 遵守有关酒精度和杂质水平的法规对于产品的安全性和有效性至关重要.
研究的目的:
- 通过评估乙醇含量和识别挥发性杂质来评估以乙醇为基础的洗手液的质量.
- 确定是否符合已确定的公共卫生指南 (CDC,WHO).
- 评估与检测到的杂质相关的潜在毒理风险.
主要方法:
- 使用头部气体染色体质谱法 (HS-GC-MS) 分析了31个手洗手液品牌.
- 通过质谱数据库分析识别挥发性杂质.
- 使用回归分析量化乙醇含量.
- 对已识别的污染物进行模拟毒理学评估.
主要成果:
- 检测到的杂质包括乙烯酸乙烯,,,乙,乙,异芽醇和其他非推的酒精.
- 71%的样本的乙醇度低于推的60%v/v,不符合CDC和WHO的标准.
- 污染与潜在的急性和慢性毒性有关.
结论:
- 很大一部分手部消毒剂不符合有效性标准,并含有有害杂质.
- 污染对使用者构成相当大的毒理风险.
- 全球消费者应该了解某些手洗手剂的潜在无效性和健康危害,无论其来源如何.
相关概念视频
Physical Properties of Alcohols and Phenols
14.1K
Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
Alcohols possess a higher boiling point than aliphatic hydrocarbons of...
Alcohols possess a higher boiling point than aliphatic hydrocarbons of...
14.1K
Volatilization
374
Volatilization gravimetry is an analytical technique that measures the mass lost due to the volatilization of the substance. This technique is used to estimate the amount of volatile material in a sample. To perform this method, heat a known amount of the sample to a high temperature in a crucible or other suitable vessel. The volatile substance in the sample evaporates, and the vapor is completely expelled from the crucible either by heating the sample or bubbling a stream of inert gas through...
374
Distillation: Vapor–Liquid Equilibria
2.7K
Distillation is a separation technique that takes advantage of the boiling point properties of disparate elements in a mixture. To perform distillation, we begin by heating a miscible mixture of two liquids with a significant difference in boiling points (at least 20°C). As the solution heats up and reaches the bubble point of the more volatile component, some molecules of the more volatile component transition into the gas phase and travel upward into the condenser, which is a glass tube...
2.7K


