在20只猫的双酸盐相关的骨死症的回顾性病例系列
Suzanna L Hatunen1, Jamie G Anderson2, Cynthia M Bell3
1Veterinary Dental Services LLC., Boxborough, MA, United States.
Frontiers in veterinary science
|September 9, 2024
概括
双酸盐相关的骨死 (BRONJ) 是一种罕见但严重的猫病,通常与阿伦德罗纳特治疗高血症有关. 在使用双酸盐之前拔牙可能会减轻风险.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 在口腔外科手术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 双酸盐药物用于治疗猫的高血症.
- 药物相关的骨 (MRONJ) 是一种罕见但严重的并发症.
- 这种情况在人类文学中更频繁地记录.
研究的目的:
- 在猫患者中描述与双酸相关的骨瘤的临床方面.
- 提高对猫的MRONJ的认识,以改善诊断和预后结果.
- 为了确定猫的MRONJ的风险因素和治疗结果.
主要方法:
- 在2015年至2021年期间,对20名被诊断患有MRONJ的猫科动物患者进行了回顾性研究.
- 收集的数据包括患者病史,双酸盐特异性,临床表现,诊断结果和治疗结果.
- 诊断是基于诊断发现与患者病史的相关性.
主要成果:
- 所有20只猫都接受了阿伦德罗纳特治疗异常性高血症.
- 85%的病例之前在病变部位进行了牙提取.
- 95%的猫需要手术,35%需要修复手术.
结论:
- 用阿伦德罗纳酸治疗的猫类异常性高血症存在MRONJ的风险.
- MRONJ病变经常与之前的牙提取部位有关.
- 理想情况下,牙科手术应在可行的情况下先进行双酸盐治疗.
相关概念视频
02:58Bronsted-Lowry Acids and Bases
The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
02:41Lethal Alleles
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
01:24Diagnosing Acidosis and Alkalosis
Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and HCO3− values are examined to...
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and HCO3− values are examined to...
01:27Acute Pancreatitis I: Introduction
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:25Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
01:21Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...