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激素受体阳性和HER-2阴性转移性乳腺癌的第一线内分泌疗法:贝叶斯网络元分析

Yi-Cheng Jiang¹, Jing-Jing Yang², Hai-Tian Zhang³

¹Department of Breast Surgery, EUSOMA Certified Breast Center, Guilin Traditional Chinese Medicine Hospital of China, Guilin, Guangxi Zhuang Autonomous Region 541002, P.R. China.

Oncology letters

|September 9, 2024

概括

帕尔博西克利布加上芳酶抑制剂 (PalboAI) 为激素受体阳性转移性乳腺癌提供了优越的无进展生存期. 这种组合被认为是最佳的维持治疗,平衡有效性和安全性.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

内分泌疗法是激素受体阳性 (HR+) / HER2-转移性乳腺癌 (mBC) 的标准.
循环素依赖激酶 (CDK) 4/6 抑制剂越来越多地使用,但对维持疗程的比较数据有限.

研究的目的:

确定HR+/HER2-mBC最有效的维持治疗方法.
为了比较各种基于CDK4/6抑制剂的疗程的疗效.

主要方法:

贝叶斯网络对16项随机对照试验 (7,174名患者,11项干预) 的元分析.
在PubMed,Embase,Cochrane图书馆,Scopus和谷歌学者中搜索到2023年8月.
使用危险比率和几率比率评估的整体存活率 (OS) 和无进展存活率 (PFS).

主要成果:

与AI单独相比,Palbociclib加AI (PalboAI) 显著延长了PFS,长达36个月.
阿贝马西克利布加富勒弗兰特,利博西克利布加富勒弗兰特,利博西克利布加AI和达尔皮西克利布加AI也在特定的时间框架内显示出与AI单独相比的显著影响.
帕尔博AI在多个时间点 (3-36个月) 显示出优异的PFS.

结论:

帕尔博西克利布加AI (PalboAI) 被确定为HR+/HER2-mBC的最佳维持治疗,考虑到疗效,安全性和合规性.
建议进行进一步的对比试验,以验证这些发现.

关键词:

贝叶斯网络元分析贝叶斯网络元分析内分泌疗法是一种内分泌疗法.激素受体阳性激素受体阳性转移性乳腺癌转移性乳腺癌受体氨酸蛋白激酶 erbB-2-阴性

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