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功能障碍与肺癌的结果之间的关联:系统性审查和元分析
Huijuan Qian1, Si Li2, Ziyun Hu1
1Department of Respiratory and Critical Care Medicine, Changxing County People's Hospital, Huzhou, Zhejiang 313100, P.R. China.
Oncology letters
|September 9, 2024
概括
患有肺癌 (LC) 和功能衰竭 (RI) 或慢性病 (CKD) 的患者的整体存活率更差. 这种并发症显著影响长期预后,特别是在早期的疾病.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
- 临床流行病学 临床流行病学
背景情况:
- 肺癌 (LC) 患者经常出现功能衰竭 (RI) 和慢性病 (CKD).
- 这些情况可能会对患者的预后和生存结果产生负面影响.
- 了解RI/CKD对LC存活率的影响对于临床管理至关重要.
研究的目的:
- 系统地评估RI/CKD与LC患者的整体存活率 (OS) 之间的关联.
- 评估RI/CKD与LC患者无病生存期 (DFS) 之间的关系.
- 综合来自RI/CKD和LC结果的观察和干预研究的证据.
主要方法:
- 在PubMed,Embase和Scopus数据库中进行全面的文献搜索.
- 包括观察性队列,病例控制研究和随机对照试验.
- 使用随机效应模型进行元分析,以计算聚合危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 与正常功能患者相比,LC和RI/CKD患者的生存状况明显恶化 (HR: 1.38,95%CI: 1.16-1.63).
- 在RI/CKD患者和没有RI/CKD患者之间没有观察到DFS的显著差异 (HR:1.12,95%CI:0.75-1.67).
- 亚组分析显示,RI/CKD和早期 (I/II) LC和不同治疗方式的低OS之间存在显著的关联.
结论:
- 功能不全/CKD对肺癌患者的整体存活率产生不利影响.
- RI/CKD的预后意义在早期肺癌中尤为明显.
- 这些发现强调了在肺癌的管理和预后中考虑功能的重要性.
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