包含2个功能障碍的寿司领域有助于膀癌患者的癌症进展
Wei-Ting Kuo1,2, Yi-Chen Lee3, Yi-Fang Yang4
1Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Journal of Cancer
|September 9, 2024
概括
含有寿司域2 (SUSD2) 在膀癌中高度表达,与晚期和低生存率相关. 它的抑制抑制了癌细胞的生长和入侵,这表明SUSD2是治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症基因组学 癌症基因组学
背景情况:
- 膀癌是台湾普遍存在的恶性瘤,需要提高诊断敏感度和治疗策略.
- 寿司域含有2 (SUSD2) 在膀癌发病的作用尚不清楚.
研究的目的:
- 研究SUSD2在膀癌中的表达,临床意义和功能作用.
- 探索SUSD2,微RNA和瘤微环境在膀癌中的关系.
主要方法:
- 癌症基因组图谱 (TCGA) 和瘤免疫估计资源 (TIMER) 数据库的分析.
- 针对SUSD2蛋白表达的免疫组织化学 (IHC).
- 功能性检测包括细胞增殖,殖民地形成,入侵和细胞周期分析.
- 微RNA (miR-383-5p) 向和功能研究.
主要成果:
- 在膀癌组织中,SUSD2的mRNA和蛋白质表达显著升高,与晚期病理和转移阶段相关.
- 高SUSD2表达与膀癌患者的整体存活率下降有关.
- 抑制SUSD2减少了膀癌细胞的扩散,殖民地形成和入侵,诱导G2/M阶段停止.
- SUSD2表达与巨细胞透和M2极化相关.
- miR-383-5p直接针对SUSD2,其表达抑制了膀癌细胞的生长和运动.
结论:
- miR-383-5p/SUSD2轴的调节失调通过影响细胞生长,转移和瘤微环境,有助于膀癌的进展.
- SUSD2代表了膀癌的潜在诊断生物标志物和治疗点.
相关概念视频
01:12Loss of Tumor Suppressor Gene Functions
4.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.7K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:20The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
01:35Cancer Cell Migration through Invadopodia
2.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.3K