TRMT10C 基因多态性赋予肝母细胞瘤易感性:来自七个中心病例控制研究的证据
Yanfei Liu1, Jinhong Zhu2, Xianqiang Wang3
1Department of Pathology, Xi'an Children's Hospital, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an 710003, Shaanxi, China.
Journal of Cancer
|September 9, 2024
概括
TRMT10C基因的遗传变异与儿童肝细胞母细胞瘤风险增加有关. 四种特定的多形态显著提高了敏感性,这表明在肝母细胞瘤倾向性中有可能进行遗传查.
科学领域:
- 表观遗传学和RNA修饰
- 癌症遗传学 癌症遗传学
- 儿科瘤学 儿科瘤学
背景情况:
- N1-甲基氨酸 (m1A) 是一种可逆的RNA表观遗传修饰,涉及各种癌症.
- 在多种癌症中观察到m1A调节者的失调,但tRNA甲基转移酶10C (TRMT10C) 在肝细胞瘤中的作用尚不清楚.
研究的目的:
- 调查TRMT10C基因多态化与中国儿童肝细胞瘤易感性之间的关联.
- 为了确定TRMT10C中的特定遗传变异,这些变异可能会产生患肝细胞瘤的风险.
主要方法:
- 一项涉及313例肝母细胞瘤病例和1446例来自中国队列的对照病例对照研究.
- 使用TaqMan实时PCR对四种TRMT10C多态 (rs7641261, rs2303476, rs4257518, rs3762735) 的基因型定型.
- 使用后勤回归分析来估计多形态和肝母细胞瘤风险之间的关联,并根据年龄和性别进行调整.
主要成果:
- 所有四种研究的TRMT10C多态都与肝细胞母细胞瘤风险的增加有显著关联.
- 在一个衰退的遗传模型下,特定的基因型显示高风险:rs7641261 (OR=1.64),rs2303476 (OR=1.87),rs4257518 (OR=1.45),和rs3762735 (OR=3.83).
- 综合分析表明,携带至少一种风险基因型显著增加了肝母细胞瘤风险 (OR=1.94),在各子组中产生一致的影响.
结论:
- 在TRMT10C基因内发现了四个新型位点,这些位点被确定为中国儿童肝母细胞瘤的易感因素.
- 这些发现突显了TRMT10C遗传变异在肝细胞母细胞瘤发展中的作用.
- 鉴定到的基因标记物可以有助于为易患肝细胞瘤的个体开发预测面板.
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