在早期精神分裂症中对结构性和功能性脑部异常的元分析
Lu Wang1,2, Ruishan Liu2, Juan Liao1,2
1Medical Imaging College, North Sichuan Medical College, Nanchong, China.
Frontiers in psychiatry
|September 9, 2024
概括
这一元分析揭示了早期精神分裂症 (EOS) 患者的显著大脑结构和功能异常,包括改变静止状态的功能性大脑活动和灰质体积. 这些发现可能为EOS诊断和治疗提供潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 之前使用rs-fMRI和VBM的研究表明,早期精神分裂症 (EOS) 患者的脑部异常.
- 限制包括小样本大小和异质结果,需要综合分析.
- 大脑结构和功能的变化与EOS的病变产生有关.
研究的目的:
- 整合先前的研究,以确定EOS患者常见和特定的大脑功能和结构异常.
- 克服小样本大小和先前研究中高异质性的局限性.
- 提供对EOS病理生理学的全面了解.
主要方法:
- 在PubMed,Web of Science,Embase,CNKI和WanFang数据库中系统搜索与EOS相关的VBM和rs-fMRI研究.
- 利用基于种子的d绘图与对象图像的变换 (SDM-PSI) 进行全脑声素元分析.
- 进行多式联运重叠分析以确定组合结构和功能异常.
主要成果:
- 包括27项研究 (28个数据集):12项关于静止状态的功能性大脑活动 (496名EOS患者,395名HC) 和15项关于灰质量 (GMV) 的研究 (458名EOS患者,531名HC).
- 在EOS患者中,左中前回形和右尾状核的休息状态功能性大脑活动增加.
- EOS患者在右上状环,右中状环和极表现出GMV的减少.
结论:
- 在EOS患者中发现了显著的结构和功能异常,特别是在回,前额叶皮和条纹体.
- 这些发现提高了对EOS病理生理机制的理解.
- 鉴定出异常可能作为EOS诊断或治疗的潜在生物标志物.
相关概念视频
Biological Causes of Schizophrenia
51
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
51
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
514
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
514
Schizophrenia
72
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
72


