影响死亡率的预后因素 患有Acinetobacter baumannii血流感染的患者
Chunrong Huang1,2, Yulian Gao1,2, Hongxia Lin1,2,3
1Department of Respiratory and Critical Care Medicine, Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Acinetobacter baumannii血流感染 (BSI) 与关键手术,ICU入院和延迟使用抗生素有关. 耐多药菌株导致更糟糕的结果和更长的住院时间,强调需要采取积极的控制措施.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 关键护理医学 关键护理医学
背景情况:
- 血流感染 Acinetobacter baumannii (BSI) 是一个重大的临床挑战.
- 了解A. baumannii BSI的临床特征和预后因素对于患者管理至关重要.
研究的目的:
- 评估诊断出Acinetobacter baumannii血流感染 (BSI) 的患者的临床特征.
- 确定与A. baumannii BSI患者的90天死亡率相关的预后因素,包括具有多药耐药 (MDR) 菌株的患者.
主要方法:
- 对200名患有A. baumannii BSI. 的住院患者进行了回顾性分析.
- 生存和死亡群体之间的临床特征比较 (30天和90天).
- 分析多药耐药 (MDR) 和敏感的A. baumannii感染之间的差异.
- 后勤回归和卡普兰-梅尔分析被用来确定预后因素和生存曲线.
主要成果:
- 在90天死亡率较高的患者中,观察到更高的抗卡巴胺感染率和ICU入院率.
- 较高的C-反应蛋白 (CRP) 和血清肌素 (Scr),较低的红细胞 (RBC) 和专蛋白 (ALB),与死亡率有关.
- 危急手术,ICU入院和延迟抗生素治疗是90天死亡率的独立预测因素.
- 与敏感菌株相比,MDR A. baumannii感染与更长的ICU/住院时间,改变的实验室值和较差的整体存活率有关.
结论:
- 关键手术,ICU入院,延迟抗生素治疗和糖尿病是A. baumannii BSI.死亡的重要危险因素.
- 耐多药A. baumannii感染与更糟糕的临床结果和长时间住院有关.
- 实施MDR A. baumannii的攻击性控制策略对于改善患者存活率至关重要.
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