逃脱病原体:抗菌素耐药性模式,风险因素和结果 - 一项对巴勒斯坦住院患者的回顾性跨部门研究
Abdallah Damin Abukhalil1, Sally Amer Barakat1, Aseel Mansour1
1Department of Pharmacy, Faculty of Pharmacy, Nursing, and Health Professions, Birzeit University, Birzeit, West Bank, State of Palestine.
Infection and drug resistance
|September 9, 2024
概括
在巴勒斯坦医院中,ESKAPE病原体中的抗菌素耐药性惊人地高,关键细菌的多药耐药性 (MDR) 超过90%. 新兴的胆素耐药性威胁着治疗选择,需要紧急的公共卫生干预措施.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 对ESKAPE病原体的抗微生物耐药性 (AMR) (Enterococcus faecium,Staphylococcus aureus,Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa和Enterobacter spp.) 已经成为一种常见的疾病. 在医疗保健机构中构成重大威胁.
- 这些病原体中的多药耐药性 (MDR) 复杂化了治疗,增加了患者的死亡率.
研究的目的:
- 在巴勒斯坦的一家三级医院确定ESKAPE病原体的抗微生物耐药性模式.
- 在感染ESKAPE病原体的住院患者中确定与多药耐药性 (MDR) 相关的因素.
主要方法:
- 一项回顾性横截面研究分析了从2021年11月到2022年11月的电子病历和实验室结果.
- 包括成人患者 (>18岁) 感染ESKAPE病原体48小时后入院.
主要成果:
- 在231名患者中,90.5%患有MDR感染. 宝曼尼菌 (Acinetobacter baumannii) (95.6%) 和肺炎菌 (Klebsiella pneumoniae) (83.8%) 的耐药性比率很高.
- 在A. baumannii,K. pneumoniae和P. aeruginosa.中观察到新兴的素耐药性. 年龄,部门和侵入性手术是MDR的风险因素.
- MDR感染与30天死亡率的增加有关 (p<0.001).
结论:
- 该研究揭示了巴勒斯坦ESKAPE病原体中MDR的惊人水平,对一线病原体产生耐药性,并出现抗素耐药性.
- 紧急实施抗菌药物管理计划,感染控制指南和政策干预措施至关重要.
- 进一步研究新的治疗方案对于应对这种日益严重的公共卫生危机至关重要.
相关概念视频
Infection
7.8K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.8K
Healthcare Associated Infections II: Preventive Measures
2.5K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.5K
Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
Pneumonia III: Complications and Assessment
188
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
188
Pneumonia I: Introduction
214
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
214


