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Updated: Jun 13, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

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综合性替代拼接分析揭示了B细胞急性淋巴细胞白血病的新预后特征

Zhiyi Zhuo1,2,3, Junfei Wang1,2,3, Yonglei Zhang1,2,3

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 197 Ruijin Er Road, Shanghai 200025, P. R. China.

International journal of biological sciences
|September 9, 2024
PubMed
概括

替代拼接 (AS) 失调影响B细胞急性淋巴细胞白血病 (B-ALL) 的进展和治疗耐药性. 一个新的18-AS签名预测患者的结果,并确定个性化B-ALL管理的治疗点.

关键词:
B细胞急性淋巴细胞白血病.替代性拼接是一种替代性的拼接.生物信息学是一种生物信息学.机器学习算法的算法预后 预测 预测 预测

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相关概念视频

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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