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住院时系统性免疫炎症指数与支气管切除症患者再入院之间的关联

Fei Gao¹, Siqi He¹, Jing Li¹

¹Department of Respiratory and Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.

Journal of inflammation research

|September 9, 2024

概括

系统性免疫炎症指数 (SII) 可以预测支气管切除症患者的再入院情况. 较高的SII水平表明,在急性恶化后,再入院的风险更高.

科学领域:

肺部医学肺部医学
免疫学免疫学免疫学
生物标志物生物标志物

背景情况:

系统性免疫炎症指数 (SII) 是一种用于系统性炎症和免疫反应的新标志物.
在各种疾病中,SII具有预后价值,但其在支气管切除症中的作用尚未确立.
支气管切除症的急性恶化与显著的发病率和医疗保健利用率有关.

研究的目的:

调查系统性免疫炎症指数 (SII) 与经历支气管炎症急性恶化患者1年再入院率之间的关联.
评估SII作为支气管切除症患者临床结果的生物标志物的预测价值.

主要方法:

一项回顾性队列研究包括521名在2020年1月至2022年1月期间入院的支气管切除症患者.
根据入院时的LOG2 (SII) 水平,患者被分为四分之一.
用单变量和多变量考克斯回归模型来评估SII和1年再录取之间的关系.

主要成果:

入院时较高的SII水平独立地与支气管切除症患者1年的再入院风险增加有关 (OR = 1.007;95% CI,1.003-1.011;p < 0.001).
患有较高SII的患者年龄较大,男性,吸烟者,BMI较低,呼吸障碍较多.
升高的SII与较高的炎症标志物和增加抗生素和葡萄皮质激素的使用有关.

结论:

住院时系统性免疫炎症指数 (SII) 升高是急性支气管炎症恶化患者1年再入院的重要预测因素.
SII显示出作为临床生物标志物的潜力,用于预测支气管切除症的结果和指导支气管切除症的管理策略.
该指数为支气管切除症护理中的风险分层和个性化治疗方法提供了有价值的工具.

关键词:

慢性呼吸道疾病慢性呼吸道疾病这是一种炎症炎症炎症炎症.预后预后预后

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