相关实验视频
Updated: Jun 13, 2025

08:56
Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
9.1K
在COVID-19患者中,FT3和长期疲劳之间的关系
Shuo Dong1, FanRui Ding1, Yuan Wang1
1Department of Endocrine and Metabolic Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in endocrinology
|September 9, 2024
概括
在COVID-19感染后持续的疲劳是常见的. 较低的自由三甲氨酸 (FT3) 水平与这种长期疲劳有关,这表明它是关键预测因素. 监测FT3可能有助于管理COVID后的情况.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 冠状病毒疾病2019 (COVID-19) 感染可能导致急性阶段后很长时间的持续疲劳.
- 了解甲状腺激素水平与COVID后疾病 (如疲劳) 之间的联系对于改善患者生活质量至关重要.
研究的目的:
- 调查甲状腺激素水平与COVID-19感染后6个月疲劳的发展之间的关联.
- 确定甲状腺激素水平作为COVID-19幸存者长期疲劳的潜在预测因素.
主要方法:
- 一项基于人口的队列研究,涉及中国大连的40名COVID-19患者 (2022年12月 - 2023年3月).
- 患者被分为疲劳和非疲劳组,基于通过6个月的电话随访进行FS-14尺度评估.
- 使用后勤回归分析来评估甲状腺激素水平与COVID后疲劳之间的关联.
主要成果:
- 在COVID-19后6个月经历疲劳的患者与非疲劳组相比,自由三铁氨酸 (FT3) 水平显著降低 (p<0.05).
- 较低的FT3水平与疲劳负相关 (OR 0.257,p<0.05),并在调整混因子 (OR 0.225,p<0.05) 后被确定为风险因素.
- 低于2.47mol/L的FT3水平被发现是预测长期疲劳的最佳切线,灵敏度为92.3%,特异性为48.1%.
结论:
- 疲劳是一种常见的后果,在COVID-19感染后至少持续6个月.
- 自由三甲状腺素 (FT3) 水平是COVID后疲劳的重要预测因素.
- 建议在COVID-19感染期间和之后密切监测FT3水平,以确定有长期疲劳风险的个人.
相关概念视频
Muscle Recovery and Fatigue
2.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.0K
Fatigue Strength of Concrete
175
Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
175
Acute Respiratory Failure-IV
131
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
131
Pneumonia II: Pathophysiology
233
The pathophysiology of pneumonia involves the following steps:
233
Fatigue
174
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
174
Acute Respiratory Failure-III
162
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
162

