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红斑结节和皮肤质和儿科炎性肠病之间的关联
Miranda L Yousif1, Andrew Ritchey2, Lucia Mirea2
1College of Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA.
Journal of pediatric gastroenterology and nutrition
|September 9, 2024
概括
儿科炎症性肠病 (IBD) 患者的结节性红疹 (EN) 和皮肤质 (PG) 与疾病严重程度的增加以及其他非皮肤问题,如关节炎和脑膜炎有关. 少数患者同时经历了EN和PG.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 皮肤病学 皮肤病学
- 临床研究是临床研究.
背景情况:
- 炎症性肠病 (IBD) 包括慢性胃肠道疾病.
- 红斑结节 (EN) 和皮肤质 (PG) 是可以发生在IBD患者的炎症性皮肤表现.
- 了解儿科IBD中EN和PG的患病率和相关因素对于全面的患者护理至关重要.
研究的目的:
- 确定诊断为IBD的儿科患者中EN和PG的发病率.
- 确定与该人口中EN和PG发展相关的患者级和访问级因素.
主要方法:
- 采用纵向队列研究设计,分析来自ImproveCareNow (ICN) 注册表的数据.
- 包括来自285,913次访问的32,497名儿科患者 (年龄≤21岁) 的数据.
- 使用纵向逻辑回归模型来评估各种因素与EN/PG存在之间的关联,控制时间和患者聚类.
主要成果:
- 在儿科IBD患者中,EN的发生率为1.57%和PG为0.90%.
- 在0.30%的患者中观察到EN和PG的同时发生.
- 无论是EN还是PG都与IBD严重程度的增加,缓解率的降低,炎症标志物的升高和其他肠外表现 (EIMs) (如关节炎和脑膜炎) 显著相关.
结论:
- 儿科IBD中的EN和PG是疾病严重程度升高的指标,与其他非皮肤EIM有关,特别是关节炎和脑膜炎.
- 一小部分儿科IBD患者可能同时经历EN和PG.
- 这些发现强调了在儿科IBD管理中对皮肤病症状的监测的重要性.
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