患有急性心肌梗塞后轻微减少排泄部位的患者心血管死亡的长期风险:一个多中心,前性注册研究
Hwajung Kim1, Kwan Yong Lee2,3, Eun Ho Choo2,3
1Division of Cardiology, Department of Internal Medicine Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea Seoul Republic of Korea.
Journal of the American Heart Association
|September 9, 2024
概括
心脏病发作后轻微减少射出分数 (mrEF) 的患者面临心血管死亡的温和风险. 一个新的得分识别了高风险个体,结果与严重减少喷射分数的人相似.
科学领域:
- 心脏病学 心脏病学
- 心血管医学 心血管医学
- 临床研究 临床研究
背景情况:
- 急性心肌梗塞 (AMI) 后轻微减少喷射分数 (mrEF) 的预后影响尚不清楚.
- 患有mrEF的AMI患者的长期心血管死亡风险需要进一步调查.
研究的目的:
- 调查 AMI 后的 mrEF 患者心血管死亡的长期风险.
- 在这个患者群体中确定心血管死亡的预测因素.
主要方法:
- 分析了来自2个前性多中心注册表的18668名患者.
- 患者的分层分为减少EF (≤40%),轻度减少EF (41%-49%) 和保存EF (≥50%) 的组.
- 在mrEF队列中开发心血管死亡的临床预测得分.
主要成果:
- 在37.9个月内,心血管死亡率为22.3% (减少EF),10.3% (mrEF) 和7.3% (保持EF).
- 在mrEF患者中,心血管死亡的独立预测因素包括65岁以上的年龄,高血压,中风,严重功能衰竭和Killip等级≥3.
- 具有>2个预测因子的预测得分确定了高风险的mrEF患者 (AUC=0.746),风险与减少的EF组相似.
结论:
- 在AMI后患有mrEF的患者心血管死亡风险中等.
- 临床预测因素可以有效地识别具有显著升高心血管死亡风险的高风险mrEF亚群.
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