在失去意识期间,横跨海马体-丘脑-mPFC通路的顺序停用
Xiaoai Chen1, Samuel R Cramer2, Dennis C Y Chan1
1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|September 9, 2024
概括
研究人员研究了使用propofol的老鼠如何失去意识. 他们发现,意识丧失 (LOC) 涉及到特定的大脑路径失活和低频大脑波的增加,为麻醉效应提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 麻醉学 麻醉学
背景情况:
- 在麻醉或睡眠期间失去意识 (LOC) 的神经机制尚未完全理解.
- 在从清醒到无意识的过渡期间调查大脑活动的变化对于理解意识本身至关重要.
研究的目的:
- 为了研究系统级神经动力学与意识丧失 (LOC) 诱导由propofol在老鼠.
- 识别特定的大脑区域和信号模式,这些区域和信号模式在LOC之前,伴随和遵循LOC.
主要方法:
- 在老鼠前带带皮层和全脑功能磁共振成像 (fMRI) 中同时进行电生理学记录.
- 逐级给予普罗波,以诱导从意识到无意识的控制过渡.
- 分析电生理学信号中的低频功率和大脑区域间的fMRI信号同步.
主要成果:
- 在LOC时刻,低频电生理功率的急剧增加被观察到.
- 在LOC之前和期间,fMRI揭示了海马体,丘陵体和中部前额叶皮层 (mPFC) 的失活级联.
- 在LOC之前检测到海马体 - thalamus-mPFC通路的同步增加,随后在持续无意识期间进行更广泛的皮质激活.
结论:
- LOC可能是由海马体,丘脑和mPFC内的连续的神经事件触发的.
- 在麻醉引起的无意识期间,皮质活动的广泛增加可能是LOC的后果,而不是原因.
- 这项研究阐明了一连串的神经事件,这些事件是过渡到无意识的基础,为LOC机制提供了洞察力.
相关概念视频
01:19Role of Hippocampus in Memory
187
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
187
01:15Subconsciousness and No Awareness
231
The concept of subconscious awareness refers to the processing of information below the level of conscious thought, which significantly influences both behaviors and decisions. It is also known as waking subconscious awareness. This complex level of cognition operates without the direct awareness of the individual, facilitating rapid and simultaneous handling of multiple information streams.
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
231
01:03Long-term Depression
2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.5K