相关实验视频

Updated: Jun 13, 2025

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

吸烟与乙型肝炎的可能性较低,表面抗原血清清除和改变宿主免疫力有关

Tsz-Yan Kwok¹, Rex Wan-Hin Hui¹, XianHua Mao¹

¹Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Journal of viral hepatitis

|September 9, 2024

概括

慢性乙型肝炎 (CHB) 患者的活跃吸烟与乙型肝炎表面抗原 (HBsAg) 血清清除的可能性较低有关. 吸烟还会增加淋巴细胞上的PD-1表达,并损害HBV特异性T细胞功能.

科学领域:

免疫学免疫学免疫学
肝病学肝病学是一种肝病学.
病毒学病毒学

背景情况:

吸烟会对慢性乙型肝炎 (CHB) 患者的临床结果产生负面影响.
吸烟对乙型肝炎表面抗原 (HBsAg) 血清清除的具体影响尚不清楚.
了解吸烟对CHB免疫反应的影响对于治疗策略至关重要.

研究的目的:

为了研究活跃吸烟对HBsAg血清清除 (SC) 在CHB患者的影响.
评估吸烟对周围血液淋巴细胞的影响,包括T细胞功能和PD-1表达.
探索吸烟,免疫细胞表型和CHB治疗结果之间的关系.

主要方法:

分析了7833名抗病毒治疗的CHB患者的纵向数据,以确定HBsAg SC率.
来自27名CHB患者 (6名吸烟者) 的外周血液单核细胞 (PBMC) 的流细胞计分析,以评估PD-1表达和调节性T细胞比例.
用HBV体对PBMC进行体外刺激,以检查HBV特异性T细胞效应因子功能,包括Treg耗尽前后的Granzyme B和TGFβ产生.

主要成果:

吸烟与HBsAg SC在5年的中位数随访期间 (aHR 0.70) 的可能性较低有关.
吸烟者在CD4+ T细胞,CD8+ T细胞和CD20+ B细胞上表现出增加的PD-1表达,与包装年相对应.
与非吸烟者相比,Treg消耗部分恢复了HBV特异性T细胞功能,在吸烟者中观察到的恢复幅度明显更大.

结论:

吸烟与在CHB患者中实现HBsAg血清清除的可能性降低有关.
吸烟通过增加淋巴细胞上的PD-1表达和损害HBV特异性T细胞效应器功能,有助于免疫失调.
这些发现强调了吸烟对免疫反应和CHB治疗结果的有害影响,表明戒烟是关键干预措施.

关键词:

这就是HBsAg.监管T细胞是T调控细胞.慢性乙型肝炎病毒感染者香烟吸烟吸烟吸烟吸烟吸烟吸烟吸烟吸烟吸烟吸烟功能性治疗治疗治疗免疫系统疲免疫系统疲

更多相关视频

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations

Published on: January 10, 2015

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

相关概念视频

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...