肥胖悖论与心脏再同步治疗装置患者全因死亡率之间的关联
Phuuwadith Wattanachayakul1,2, Panat Yanpiset3, Chalothorn Wannaphut4
1Department of Medicine, Jefferson Einstein Hospital, Philadelphia, Pennsylvania, USA.
Pacing and clinical electrophysiology : PACE
|September 9, 2024
概括
肥胖悖论表明,使用心脏再同步治疗 (CRT) 设备的超重和肥胖患者的生存率更好. 体重不足的人面临更高的死亡风险,突出显示BMI.
科学领域:
- 心脏病学 心脏病学
- 肥胖问题研究研究
- 医学统计 医学统计
背景情况:
- 肥胖悖论存在于心血管疾病中,但其对心脏再同步治疗 (CRT) 结果的影响尚不清楚.
- 身体质量指数 (BMI) 和肥胖对CRT患者存活时间的影响需要澄清.
研究的目的:
- 研究使用CRT设备的患者的BMI和全因死亡率之间的关联.
- 综合现有关于CRT人口中肥胖悖论的数据.
主要方法:
- 在2024年1月之前对Medline和EMBASE数据库进行系统审查.
- 包括12项考查BMI状态和CRT患者全因死亡率的队列研究.
- 使用通用逆方差方法对相对风险 (RR) 和危险比率 (HR) 进行元分析.
主要成果:
- 与正常体重患者相比,使用CRT的超重和肥胖患者的全因死亡率显著降低 (RR分别为0.77和0.81).
- 体重不足的CRT患者有较高的全因死亡风险 (RR 1.37).
- 作为连续变量,增加的BMI与全因死亡率的降低有关 (HR 0.94).
结论:
- 在CRT患者中观察到明显的肥胖悖论:超重/肥胖与降低死亡率有关,体重不足与增加死亡率有关.
- 研究结果表明,BMI影响CRT患者的存活率,在更高的体重类别中具有保护作用,在体重不足中具有有害作用.
- 需要进行进一步的研究,以阐明CRT患者在BMI范围内的治疗机制和临床影响.
关键词:
这就是为什么BMI是BMI.身体质量指数 (BMI) 是指身体质量指数.心脏再同步治疗心脏再同步治疗这是一个元分析.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖肥胖的悖论 肥胖的悖论系统性审查 系统性审查更多相关视频
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