在患有腺囊缩症的儿科患者中,喉和鼻腔微生物群的变化
Federica Del Chierico1, Antonia Piazzesi1, Ersilia Vita Fiscarelli2
1Research Unit of Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Microbiology spectrum
|September 9, 2024
概括
益生菌治疗改善了患有腺囊缩症 (AH) 的儿童的上呼吸道微生物群,减少了感染和潜在的有害细菌. 这为管理AH症状提供了一个非手术的选择.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 腺囊缩 (AH) 是儿科睡眠呼吸障碍的主要原因,经常导致手术干预.
- 包括益生菌在内的非手术辅助疗法正在引起人们的兴趣,以潜在地减少桃体切除/腺切除的需要.
研究的目的:
- 与健康对照组相比,对患有AH的儿童进行喉和鼻腔微生物群的研究.
- 评估益生菌口服喷雾治疗对AH患者微生物群组成和上呼吸道感染 (URTI) 的影响.
主要方法:
- 基于16S rRNA的甲状腺经济学和轴突培养被用于分析来自57名AH患者和65名健康儿童的喉和鼻.
- AH患者被随机分配到益生菌和安慰剂组进行5个月的治疗过程,采集了治疗前和后的样本.
主要成果:
- 与健康儿童相比,AH患者表现出明显的喉和鼻腔微生物群,其Rothia,Granulicatella,Streptococcus,Neisseria和Haemophilus增加,而Corynebacterium,Pseudomonas,Acinetobacter和Moraxella减少.
- 益生菌治疗没有显示任何不良影响,减少了URTI发病率,并通过减少像Haemophilus spp.这样的病原生物来积极调节喉微生物群.
- 具体来说,益生菌降低了Streptococcus mitis和Gemella血溶菌的丰富性,与AH严重程度相关.
结论:
- 喉和鼻腔微生物群的变化与儿童的腺囊缩有关.
- 益生菌的使用提供了对URTI的保护,并减少了AH患者中病原生物的存在.
- 这种微生物疗法可以作为AH的有效辅助治疗,可能减少对手术的需要.
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