相关实验视频

Updated: Jun 13, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

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Published on: July 17, 2020

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通过降解PTPN14,HPV18E7抑制LATS1激酶,并通过降解PTPN14激活YAP1

William J Blakely1, Joshua Hatterschide1, Elizabeth A White1

  • 1Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

mBio
|September 9, 2024
PubMed
概括

高风险的人类乳头瘤病毒 (HPV) 蛋白E7降解瘤抑制剂PTPN14,抑制Hippo通路. 这促进了YAP1的活动,驱动了角质细胞干和阻断分化,从而导致HPV驱动的致癌症.

关键词:
河马河马是什么意思 海马河马是什么意思PTPN14 PTPN14 在线观看一个YAP1一个YAP1不同化的差异化差异化.人类乳头瘤病毒人类乳头瘤病毒质细胞 (keratinocyte) 是一种细胞.这是一种瘤抑制剂.

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