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[膜巨细胞在艾滋病毒持续性和肺部疾病中的潜在作用]

Cecilia T Costiniuk¹, Suzanne Samarani², Lixing Wang³

¹Programme en maladies infectieuses et immunité en santé mondiale, Institut de recherche du Centre universitaire de santé McGill, Montréal, QC, Canada, Département de Médecine expérimentale, Université McGill, Montréal QC, Canada.

Virologie (Montrouge, France)

|September 9, 2024

概括

膜巨细胞 (AM) 可能在人类免疫缺陷病毒 (HIV) 持久性和艾滋病毒感染者慢性肺病 (PLWH) 中发挥关键作用. 消除感染AM的策略可能对实现艾滋病毒治愈至关重要.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
肺部病理学肺部病理学

背景情况:

抗逆转录病毒疗法 (ART) 改善了艾滋病毒感染者 (PLWH) 的预期寿命,但持续的艾滋病毒储存阻碍了治愈.
患有PLWH的人患有多重疾病,特别是肺部疾病的负担更高,这可能与包括肺在内的各种组织中的HIV储存器有关.

研究的目的:

讨论膜巨细胞 (AM) 在人类免疫缺陷病毒 (HIV) 持久性中的潜在作用.
探索AM对PLWH肺炎和免疫失调的贡献.
讨论消除艾滋病毒感染的AM的策略.

主要方法:

对PLWH中艾滋病毒储存库,膜巨细胞和肺部疾病的现有文献的综述.
分析艾滋病毒感染,肺部环境和免疫细胞功能之间的相互作用.

主要成果:

膜巨细胞 (AM),是胚胎起源的长寿细胞,携带艾滋病毒,并为肺部的病毒储库做出贡献.
肺免疫细胞,包括AM,由于不断的抗原刺激,可以变得疲和衰老,从而促进HIV的持久性.
吸烟和同时感染等因素会加剧炎症,促进HIV复制和免疫失调,增加患慢性肺病的易感性.

结论:

膜巨细胞 (AM) 涉及艾滋病毒的持久性和慢性肺病 (PLWH) 的发展,即使在ART.
针对艾滋病毒感染的AM可能是一个可行的策略,以解决艾滋病毒储量和改善PLWH的肺部健康.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒艾滋病毒持久性艾滋病毒持久性艾滋病病毒的储存库膜细胞巨细胞肺免疫肺免疫肺免疫

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