作为IgA血管炎的诱因的SARS-CoV-2:一个临床病例和文献综述
Akerke Auanassova1, Marlen Yessirkepov1, Burhan Fatih Kocyigit2
1Department of Biology and Biochemistry, South Kazakhstan Medical Academy, Shymkent, Kazakhstan.
严重的急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 感染可以引发IgA血管炎 (IgAV),一种自身免疫性疾病. 早期诊断和用皮质类固醇治疗可以改善患者的治疗结果,正如最近的一项案例研究表明的那样.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19),由SARS-CoV-2引起,与各种自身免疫和炎症状况有关.
- 越来越多的证据表明,免疫球蛋白A (IgA) 参与了对SARS-CoV-2的免疫反应,特别是在IgA免疫复合体沉积疾病中,如IgA血管炎 (IgAV).
研究的目的:
- 报告由SARS-CoV-2感染引发的IgA血管炎 (IgAV) 病例.
- 为提供之前发表的IgAV病例在SARS-CoV-2感染后的概述.
- 提醒风湿病学家和专家了解COVID-19相关IgAV的临床特征,诊断和治疗.
主要方法:
- 一个53岁的男性患有SARS-CoV-2和随后的IgAV症状的病例报告.
- 对与SARS-CoV-2相关的IgAV病例现有文献的审查.
- 临床评估和治疗所呈现的病例.
主要成果:
- 患者呈现出特征性IgAV症状,包括皮肤皮疹,关节疼痛,腹痛和高血压.
- 用静脉注射和口服甲基普雷迪尼索隆治疗导致明显改善,疼痛和皮疹消失.
- 文献审查证实了SARS-CoV-2感染后的IgAV的模式.
结论:
- 由于SARS-CoV-2可以导致IgA血管炎 (IgAV),因此需要提高临床医生的意识.
- 及时诊断和皮质类固醇治疗是有效的管理COVID-19相关的IgAV.
- 需要进一步的研究才能充分理解将SARS-CoV-2与IgAV联系在一起的机制.
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